- Does not respond to you, has trouble waking up, or is limp
- Has trouble breathing
- Has blue lips, tongue, or nails
- Starts to lean forward and drool
- Is an infant, and the soft spot on his or her head seems to be bulging or caving in
- Has a stiff neck
- Has a severe headache
- Has severe belly pain
- Has a rash or purple spots that look like bruises on the skin (that were not there before he or she got sick)
- Refuses to drink anything or seems too sick to drink enough
- Will not stop crying
- Is very cranky or irritable
- Has diarrhea that lasts more than two to three days or seems to be getting worse
- Has vomiting that goes on for more than one day
- Seems to be dehydrated (signs include urinating less than usual, not having tears when crying, being less alert and less active than usual)
- Has a specific symptom, such as a sore throat or ear pain
- Has pain when he or she urinates